Issue Archive

Role of NLRP3 inflammasome in diabetes mellitus and exercise intervention

WEN Rui-Ming¹, LYU Hong-Yan^1,2, CHANG Bo¹, YI Xue-Jie^1,3,*

¹School of Sports and Human Sciences, Shenyang Sport University, Shenyang 110102, China；²School of Physical Education, Liaoning Normal University, Dalian 116029, China；³Sports Social Science Research Center, Shenyang Sport University, Shenyang 110102, China

Abstract

Chronic inflammatory reaction has been established as an important sign of the occurrence and development of diabetes mellitus (DM), accompanied by the production of a large number of inflammatory factors, thus aggravating the disease progression. As an important non-invasive intervention measure to inhibit inflammation, exercise plays a very important role in the amelioration of DM. NOD-like receptor protein 3 (NLRP3) inflammasome, a regulatory factor of inflammatory response, can induce a variety of inflammatory cascades and cell death, which are closely related to glucose uptake and dyslipidemia regulation. The development of DM can be postponed with exercise. Previous studies have reported the effects of NLRP3 inflammasome on DM, but the crucial role of exercise in this process remains unclear. Therefore, this paper reviews the research progress on the improving effects of exercise intervention on the symptoms of DM by mediating NLRP3 inflammasome, providing a novel theoretical foundation for understanding the prevention and treatment of DM through exercise. 

Key words: NLRP3 inflammasome; diabetes mellitus; exercise

Received: 　　Accepted:

Corresponding author: 衣雪洁　　E-mail: yixuejie8387@163.com

DOI: 10.13294/j.aps.2023.0053

Citing This Article：

WEN Rui-Ming, LYU Hong-Yan, CHANG Bo, YI Xue-Jie. Role of NLRP3 inflammasome in diabetes mellitus and exercise intervention. Acta Physiol Sin 2023; 75 (6): 788-798 (in Chinese with English abstract).