The research progress of high altitude environment-associated chronic obstructive pulmonary disease and therapeutic drugs
ZENG Xiang-Hai1,2,3, SUONAN Ge-Le4, HUANG Qin1, LI Yu1,2,3, ZHANG Xiao-Jing1, LI Wen-Bin1,2,3, WANG Rong1,2,3,*
1Department of Pharmacy, the 940th Hospital of the Joint Logistic Support Force, Lanzhou 730050, China；2School of Pharmacy, Ningxia Medical University, Yinchuan 750004, China；3Gansu Plateau Pharmaceutical Technology Center, Lanzhou 730050, China；4Department of Internal Medicine, Qinghai Yushu People’s Hospital, Yushu 815099, China
The plateau environment is characterized by low oxygen, low air pressure, low temperature, and strong ultraviolet rays, etc. Chronic obstructive pulmonary disease (COPD) is a preventable and treatable chronic lung disease. High altitude environment increases COPD prevalence, clinical manifestation and mortality. The therapeutic window of theophylline drugs for COPD is narrow, and the high altitude environment has an influence on the pharmacokinetics of the drugs. This review summarizes the differences in the prevalence, mortality, clinical manifestation and clinical symptoms of COPD in the plateau and plain, providing a basis for identifying the risk factors of COPD in the plateau areas. The effects of plateau hypoxic environment on the pharmacokinetics of COPD drugs were also discussed. It can provide a rationale for more effective prevention and treatment of COPD at high altitude.
Corresponding author: WANG Rong E-mail: email@example.com,firstname.lastname@example.org,email@example.com
Citing This Article：
ZENG Xiang-Hai, SUONAN Ge-Le, HUANG Qin, LI Yu, ZHANG Xiao-Jing, LI Wen-Bin, WANG Rong. The research progress of high altitude environment-associated chronic obstructive pulmonary disease and therapeutic drugs. Acta Physiol Sin 2023; 75 (5): 691-702