Issue Archive

Progress on the role of Kalirin-7 in exercise intervention-mediated improvement of neurodegenerative diseases 

YU Meng-Yuan, TIAN Zhen-Jun^*

Institute of Sports and Exercise Biology, Shaanxi Normal University, Xi’an 710119, China

Abstract

Guanine nucleotide exchange factor Kalirin-7 (Kal-7) is a key factor in synaptic plasticity and plays an important regulatory role in the brain. Abnormal synaptic function leads to the weakening of cognitive functions such as learning and memory, accompanied by abnormal expression of Kal-7, which in turn induces a variety of neurodegenerative diseases. Exercise can upregulate the expression of Kal-7 in related brain regions to alleviate neurodegenerative diseases. By reviewing the literature on Kal-7 and neurodegenerative diseases, as well as the research progress of exercise intervention, this paper summarizes the role and possible mechanism of Kal-7 in the improvement of neurodegenerative diseases by exercise and provides a new rationale for the basic and clinical research on the prevention and treatment of neurodegenerative diseases by exercise. 

Key words: Kalirin-7 (Kal-7); neurodegenerative diseases; synaptic plasticity; exercise

Received: 　　Accepted:

Corresponding author: 田振军　　E-mail: tianzhj@snnu.edu.cn

DOI: 10.13294/j.aps.2023.0069

Citing This Article：

YU Meng-Yuan, TIAN Zhen-Jun. Progress on the role of Kalirin-7 in exercise intervention-mediated improvement of neurodegenerative diseases . Acta Physiol Sin 2023; 75 (5): 659-670 (in Chinese with English abstract).