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Progress on mRNA vaccine for the prevention of major infectious diseases in humans and animals

GAO Jia-Qi¹, ZHAO Xian-Jun^1,2, HUA Jin-Lian^1,*

¹Shaanxi Stem Cell Engineering and Technology Research Center, College of Veterinary Medicine, Northwest Agriculture and Forestry University, Yangling 712100, China；²Baioupai (Tianjin) Biotechnology Co., Ltd., Tianjin 300350, China

Abstract

A large number of studies have demonstrated that mRNA vaccine has been characterized as a technique with good safety, strong immunogenicity and high developmental potential, which makes it have broad prospects in immunotherapy. In recent years, the stability and in vivo delivery efficiency of mRNA vaccines have been largely addressed by the progresses in mRNA engineering and delivery innovation. And some mRNA vaccines are now clinical approved or in preclinical trials. Here, we summarize current knowledge on the research advances, technology, and application in major infectious diseases in humans and animals of mRNA vaccines, with the aim to provide a reference for improving the development of novel mRNA vaccines.

Key words: mRNA vaccine; infectious diseases; delivery system

Received: 　　Accepted:

Corresponding author: 华进联　　E-mail: jinlianhua@nwsuaf.edu.cn

DOI: 10.13294/j.aps.2023.0058

Citing This Article：

GAO Jia-Qi, ZHAO Xian-Jun, HUA Jin-Lian. Progress on mRNA vaccine for the prevention of major infectious diseases in humans and animals. Acta Physiol Sin 2023; 75 (5): 647-658 (in Chinese with English abstract).