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Progress on the mechanism and treatment of Parkinson's disease-related pathological pain

TANG Lin-Lin¹, YOU Hao-Jun^1,2, LEI Jing^1,2,*

¹Center for Translational Medicine Research on Sensory-Motor Diseases, Yan’an University, Yan’an 716000, China；²Key Laboratory of Yan’an Sports Rehabilitation Medicine, Yan’an 716000, China

Abstract

Parkinson’s disease (PD) is a common neurodegenerative disease characterized by motor symptoms, including bradykinesia, resting tremor, and progressive rigidity. More recently, non-motor symptoms of PD, such as pain, depression and anxiety, and autonomic dysfunction, have attracted increasing attention from scientists and clinicians. As one of non-motor symptoms, pain has high prevalence and early onset feature. Because the mechanism of PD-related pathological pain is unclear, the clinical therapy for treating PD-related pathological pain is very limited, with a focus on relieving the symptoms. This paper reviewed the clinical features, pathogenesis, and therapeutic strategies of PD-related pathological pain and discussed the mechanism of the chronicity of PD-related pathological pain, hoping to provide useful data for the study of drugs and clinical intervention for PD-related pathological pain.

Key words: Parkinson’s disease; pain; endogenous descending pain modulation; thalamus

Received: 　　Accepted:

Corresponding author: 雷静　　E-mail: jinglei_2000@126.com

Citing This Article：

TANG Lin-Lin, YOU Hao-Jun, LEI Jing. Progress on the mechanism and treatment of Parkinson's disease-related pathological pain. Acta Physiol Sin 2023; 75 (4): 595-603 (in Chinese with English abstract).