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Research advances on the role of ACSL3 in the atherosclerosis

YANG Li, YUAN Zhong-Hua^*

Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Hengyang Medical School, University of South China, Hengyang 421001, China

Abstract

Lipids droplets are organelles that store neutral lipids and are closely related to lipid accumulation. Long chain acyl-coenzyme A synthetase 3 (ACSL3) is a lipid droplet-associated protein mainly distributed in the cell membrane, endoplasmic reticulum, and intracellular lipid droplets, and its distribution depends on cell type and fatty acid supply. ACSL3 is a key regulator of fatty acid metabolism that is closely related to intracellular lipid accumulation, and plays an important role in various pathophysiological processes such as lipid droplet synthesis and lipid metabolism, cellular inflammation, and ferroptosis. This paper mainly reviews the role of ACSL3 in lipid synthesis, ferroptosis, and inflammatory response, with focus on the mechanism of its role in lipid accumulation in atherosclerosis, and provides new ideas for exploring potential therapeutic targets in atherosclerotic diseases.

Key words: long chain acyl-coenzyme A synthetase 3 (ACSL3); atherosclerosis; lipid accumulation; lipid droplet

Received: 　　Accepted:

Corresponding author: 袁中华　　E-mail: yzh5555@163.com

Citing This Article：

YANG Li, YUAN Zhong-Hua. Research advances on the role of ACSL3 in the atherosclerosis. Acta Physiol Sin 2023; 75 (4): 587-594 (in Chinese with English abstract).