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Research progress on regulation of N⁶-adenylate methylation modification in lipid metabolism disorders

CHEN Shu-Ya, NI An-Yu, QIAN Qiu-Hui, YAN Jin, WANG Xue-Dong, WANG Hui-Li^*

School of Environmental Science and Engineering, Suzhou University of Science and Technology, Suzhou 215009, China

Abstract

Lipid metabolism is a complex physiological process, which is closely related to nutrient regulation, hormone balance and endocrine function. It involves the interactions of multiple factors and signal transduction pathways. Lipid metabolism disorder is one of the main mechanisms to induce a variety of diseases, such as obesity, diabetes, non-alcoholic fatty liver disease, hepatitis, hepatocellular carcinoma and their complications. At present, more and more studies have found that the “dynamic modification” of N6-adenylate methylation (m⁶A) on RNA represents a new “post-transcriptional” regulation mode. m⁶A methylation modification can occur in mRNA, tRNA, ncRNA, etc. Its abnormal modification can regulate gene expression changes and alternative splicing events. Many latest references have reported that m⁶A RNA modification is involved in the epigenetic regulation of lipid metabolism disorder. Based on the major diseases induced by lipid metabolism disorders, we reviewed the regulatory roles of m⁶A modification in the occurrence and development of those diseases. These overall findings inform further in-depth investigations of the underlying molecular mechanisms regarding the pathogenesis of lipid metabolism disorders from the perspective of epigenetics, and provide reference for health prevention, molecular diagnosis and treatment of related diseases.

Key words: lipid metabolism disorder; obesity; type 2 diabetes; non-alcoholic fatty liver disease; hepatocellular carcinoma; m6A RNA modification; epigenetic inheritance

Received: 　　Accepted:

Corresponding author: 王慧利　　E-mail: whuili@163.com

Citing This Article：

CHEN Shu-Ya, NI An-Yu, QIAN Qiu-Hui, YAN Jin, WANG Xue-Dong, WANG Hui-Li. Research progress on regulation of N⁶-adenylate methylation modification in lipid metabolism disorders. Acta Physiol Sin 2023; 75 (3): 439-450 (in Chinese with English abstract).