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Research progress in control strategies of biological clock disorder

PENG Jing1, REN Bao-Yin1, ZHANG He1, CHEN Li-Hong2, YANG Guang-Rui1,*

1School of Bioengineering, Dalian University of Technology, Dalian 116024, China;2Advanced Institute for Medical Sciences, Dalian Medical University, Dalian 116044, China

Abstract

Circadian clock is an internal mechanism evolved to adapt to cyclic environmental changes, especially diurnal changes. Keeping the internal clock in synchronization with the external clock is essential for health. Mismatch of the clocks due to phase shift or disruption of molecular clocks may lead to circadian disorders, including abnormal sleep-wake cycles, as well as disrupted rhythms in hormone secretion, blood pressure, heart rate, body temperature, etc. Long-term circadian disorders are risk factors for various common critical diseases such as metabolic diseases, cardiovascular diseases, and tumor. To prevent or treat the circadian disorders, scientists have conducted extensive research on the function of circadian clocks and their roles in the development of diseases, and screened hundreds of thousands of compounds to find candidates to regulate circadian rhythms. In addition, melatonin, light therapy, exercise therapy, timing and composition of food also play a certain role in relieving associated symptoms. Here, we summarized the progress of both drug- and non-drug-based approaches to prevent and treat circadian clock disorders.


Key words: biological rhythm; circadian disorder; drug therapy; non-drug intervention

Received:   Accepted:

Corresponding author: 杨光锐  E-mail: guangrui.yang@hotmail.com

DOI: 10.13294/j.aps.2023.0021

Citing This Article:

PENG Jing, REN Bao-Yin, ZHANG He, CHEN Li-Hong, YANG Guang-Rui. Research progress in control strategies of biological clock disorder. Acta Physiol Sin 2023; 75 (2): 279-290 (in Chinese with English abstract).