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Research progress of ferroptosis in hypoxia-associated brain injury 

CHANG Xi-Wen^1,2, ZHAO An-Peng^1,2, YAO Wan-Teng^1,2, LI Wen-Bin¹, WANG Rong^1,2,*

¹Department of Pharmacy, The 940th Hospital of PLA Joint Logistics Support Force, Lanzhou 730050, China；²School of Pharmacy, Lanzhou University, Lanzhou 730000, China

Abstract

Cerebral hypoxia often brings irreversible damage to the central nervous system, which seriously endangers human health. It is of great significance to further explore the mechanism of hypoxia-associated brain injury. As a programmed cell death, ferroptosis mainly manifests as cell death caused by excessive accumulation of iron-dependent lipid peroxides. It is associated with abnormal glutathione metabolism, lipid peroxidation and iron metabolism, and is involved in the occurrence and development of various diseases. Studies have found that ferroptosis plays an important role in hypoxia-associated brain injury. This review summarizes the mechanism of ferroptosis, and describes its research progress in cerebral ischemia reperfusion injury, neonatal hypoxic-ischemic brain damage, obstructive sleep apnea-induced brain injury and high-altitude hypoxic brain injury.

Key words: ferroptosis; high-altitude hypoxia; ischemia-reperfusion; hypoxic-ischemic brain damage; obstructive sleep apnea; intermittent hypoxia

Received: 　　Accepted:

Corresponding author: 王荣　　E-mail: wangrong-69@163.com

DOI: 10.13294/j.aps.2023.0018

Citing This Article：

CHANG Xi-Wen, ZHAO An-Peng, YAO Wan-Teng, LI Wen-Bin, WANG Rong. Research progress of ferroptosis in hypoxia-associated brain injury . Acta Physiol Sin 2023; 75 (2): 255-268 (in Chinese with English abstract).