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Research progress on the immunomodulatory effects and mechanisms of trace amine-associated receptor 1

ZHANG Xian-Qiang, LI Ji-Tao, SI Tian-Mei, SU Yun-Ai^*

Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing 100191, China

Abstract

Trace amines are endogenous molecules distributed in the central nervous system and peripheral tissues that resemble common biogenic amines in terms of subcellular localization, chemical structure, and metabolism. Trace amine-associated receptor (TAAR) is a kind of evolutionarily conserved G-protein-coupled receptors in vertebrates, in which TAAR1 is a functional regulator of monoamine transmitters such as dopamine and serotonin. TAAR1 is widely considered as a potential therapeutic target for schizophrenia, depression and drug addiction. Moreover, TAAR1 is also expressed in peripheral tissues. The homeostasis imbalance of trace aminergic system can induce over-activation of peripheral immune system and central immune inflammatory response. TAAR1 modulators are becoming potential emerging drugs for the treatment of immune-related illnesses, because they may play a major role in the activation or modulation of immune response.

Key words: trace amine-associated receptor 1; immune response; neuroimmunomodulation; tumor immunity

Received: 　　Accepted:

Corresponding author: 苏允爱　　E-mail: suyunai@bjmu.edu.cn

DOI: 10.13294/j.aps.2023.0004

Citing This Article：

ZHANG Xian-Qiang, LI Ji-Tao, SI Tian-Mei, SU Yun-Ai. Research progress on the immunomodulatory effects and mechanisms of trace amine-associated receptor 1. Acta Physiol Sin 2023; 75 (2): 248-254 (in Chinese with English abstract).