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New mechanisms of chronic kidney disease-associated vascular calcification

WANG Pei-Wen, ZHANG Ai-Hua^*

Xuanwu Hospital of Capital Medical University, Beijing 100053, China

Abstract

Vascular calcification is the crucial factor of high cardiovascular disease morbidity and mortality in patients with chronic kidney disease (CKD), which causes a huge medical and economic burden. It is urgent to explore its pathogenesis and intervention methods. CKD-associated vascular calcification is an ectopic osteogenesis process actively regulated by multiple cells. Vascular smooth muscle cells (VSMCs) undergo osteogenic differentiation in a pro-calcification environment, and secrete matrix vesicles to form calcium and phosphorus crystal deposition sites, which are key events in the development of CKD-associated vascular calcification. This article reviews the new mechanism and technology of CKD-associated vascular calcification and discusses the role of the myokine Irisin in CKD-associated vascular calcification.

Key words: chronic kidney disease; vascular calcification; pathogenesis; Irisin

Received: 　　Accepted:

Corresponding author: 张爱华　　E-mail: zhangaihua0982@sina.com

Citing This Article：

WANG Pei-Wen, ZHANG Ai-Hua. New mechanisms of chronic kidney disease-associated vascular calcification. Acta Physiol Sin 2022; 74 (6): 913-926 (in Chinese with English abstract).