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Role and mechanism of hydrogen sulfide in vascular calcification

MA Jian-Shuai¹, CHEN Jie², HUANG Hui^1,*

¹Department of Cardiology, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen 518033, China；²Department of Radiation Oncology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510000, China

Abstract

Vascular calcification is a common pathological process in patients with diabetes, chronic kidney disease, and cardiovascular disease, manifested by the deposition of hydroxyapatite on the walls of blood vessels. Hydrogen sulfide is the third gas signal molecule found in mammals after nitric oxide and carbon monoxide, which has anti-inflammatory, antioxidant stress and other effects in the cardiovascular system. In recent years, it has been recognized that hydrogen sulfide has an anti-vascular calcification effect, and supplementation with hydrogen sulfide and its donors can alleviate vascular calcification. In this review, we discussed the various evidence of the protective effect of hydrogen sulfide on vascular calcification, and highlighted the hydrogen sulfide metabolism changes and the potential regulatory mechanisms of hydrogen sulfide on the pathophysiological changes in vascular calcification.

Key words: vascular calcification; hydrogen sulfide; metabolism

Received: 　　Accepted:

Corresponding author: 黄辉　　E-mail: huanghui765@hotmail.com

Citing This Article：

MA Jian-Shuai, CHEN Jie, HUANG Hui. Role and mechanism of hydrogen sulfide in vascular calcification. Acta Physiol Sin 2022; 74 (6): 903-912 (in Chinese with English abstract).