Issue Archive

Role of non-coding RNAs in vascular smooth muscle cell calcification

YU Hang¹, ZHU Da-Ling^1,2,*

¹Branch Campus of Daqing, Harbin Medical University, Daqing 163311, China；²2College of Pharmacy, Harbin Medical University, Harbin 158100, China

Abstract

Vascular calcification, the deposition of calcium in the arterial wall, is often linked to increased stiffness of the vascular wall. Vascular calcification is one of the important factors for high morbidity and mortality of cardiovascular and cerebrovascular diseases, as well as an important biomarker in atherosclerotic cardiovascular events, stroke and peripheral vascular diseases. The mechanism of vascular calcification has not been fully elucidated. Recently, non-coding RNAs have been found to play an important role in the process of vascular calcification. In this paper, the main types of non-coding RNAs and their roles involved in vascular smooth muscle cell calcification are reviewed, including the changes of osteoblast-related proteins, calcification signaling pathways and intracellular Ca²⁺.

Key words: vascular calcification; vascular smooth muscle cells; non-coding RNAs

Received: 　　Accepted:

Corresponding author: 朱大岭　　E-mail: dalingz@yahoo.com

Citing This Article：

YU Hang, ZHU Da-Ling. Role of non-coding RNAs in vascular smooth muscle cell calcification. Acta Physiol Sin 2022; 74 (6): 885-893 (in Chinese with English abstract).