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Consensus and controversy on research progress and clinical practice of vascularcalcification

HUANG Hui¹, ZHANG Ai-Hua², CHEN Jing³, YUAN Ling-Qing^4,*

¹The Eight Affiliated Hospital, Sun Yat-sen University, Shenzhen 518033, China；²Xuanwu Hospital of Capital Medical University, Beijing 100053, China；³Huashan Hospital, Fudan University, Shanghai 200040, China；⁴The Second Xiangya Hospital of Central South University, Changsha 410011, China

Abstract

Vascular calcification is an active and complex pathological process regulated by several factors. Vascular calcification is closely related to the incidence and mortality of the cardiovascular disease, chronic kidney disease and other diseases, which affects multiple organs and systems, thus affecting people’s health. Therefore, more and more attention is paid to vascular calcification. At present, the pathogenesis and clinical practice of vascular calcification have been continuously improved, which mainly includes calcium and phosphorus imbalance theory, vascular smooth muscle cell transdifferentiation theory, bone homeostasis imbalance theory, epigenetic regulation theory, inflammation theory, extracellular matrix theory, new cell fate theory and so on. However, there are still many unsolved problems. Since the occurrence and development of vascular calcification affect multiple organs and systems, this expert consensus gathered clinicians and basic research experts engaged in the study of vascular calcification in order to summarize the progress of various disciplines related to vascular calcification in recent years. The purpose of this consensus is to systematically summarize the latest research progress, treatment consensus and controversy of vascular calcification from the aspects of epidemiology, pathogenesis, prevention and treatment, so as to provide theoretical basis and clinical enlightenment for in-depth research in this field.

Key words: vascular calcification; epidemiology; mechanism progress; consensus and controversy in clinical practice

Received: 　　Accepted:

Corresponding author: 袁凌青　　E-mail: allenylq@csu.edu.cn

Citing This Article：

HUANG Hui, ZHANG Ai-Hua, CHEN Jing, YUAN Ling-Qing. Consensus and controversy on research progress and clinical practice of vascularcalcification. Acta Physiol Sin 2022; 74 (6): 859-884 (in Chinese with English abstract).