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Contributions of impaired adult hippocampal neurogenesis to occurrence and development of diabetic encephalopathy 

ZHANG Qi, XU Shun-Jiang^*

Central Laboratory of the First Hospital of Hebei Medical University, Hebei Provincial Brain Science International Joint Research Center, Hebei Provincial Key Laboratory of Brain Science and Mental and Psychological Diseases, Shijiazhuang 050031, China

Abstract

Diabetic encephalopathy (DE) is one of the most common complications of diabetes mellitus (DM). Persistent hyperglycemia in DM patients may induce numerous pathophysiological changes, such as chronic inflammation, increased permeability of blood-brain barrier, impaired neurogenesis, and brain atrophy, which eventually impair cognitive function. The dentate gyrus (DG) of hippocampus is a crucial region for learning and memory, as well as adult neurogenesis in mammals. Recent studies have shown that adult hippocampal neurogenesis (AHN) exists throughout life and is decreased with age, whereas AHN is significantly impaired in DE. Therefore, numerous efforts are currently focused on exploring the mechanisms underlying cognitive impairment induced by AHN dysfunction in DE. Here, we summarize studies on the contributions of AHN disorders to the occurrence and development of DE and related mechanisms, in order to shed light on the prevention and treatment of DE.

Key words: diabetic encephalopathy; adult hippocampal neurogenesis; neuroinflammation; neural stem cells

Received: 　　Accepted:

Corresponding author: 许顺江　　E-mail: sjxu66@hotmail.com

DOI: 10.13294/j.aps.2022.0040

Citing This Article：

ZHANG Qi, XU Shun-Jiang. Contributions of impaired adult hippocampal neurogenesis to occurrence and development of diabetic encephalopathy . Acta Physiol Sin 2022; 74 (5): 837-842 (in Chinese with English abstract).