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Research progress on the regulation mechanisms of iron metabolism in anemia of chronic disease

MI Hai-Chao¹, CUI Fang², DU Yu-Tao¹, WANG Ruo-Tong¹, ZHANG Rui¹, SHI Min^2,*

¹Department of Clinical Laboratory, Second Hospital of Hebei Medical University, Shijiazhuang 050000, China；²Department of Electron Microscopy Laboratory Centre, Hebei Medical University, Shijiazhuang 050017, China

Abstract

Anemia of chronic disease (ACD), complicated by various chronic inflammatory diseases, is the second most prevalent type of anemia after iron deficiency anemia in the world. ACD significantly reduces the life quality of patients with chronic diseases, and represents an independent poor prognostic factor in certain chronic diseases. A large body of studies has demonstrated that most of anemia is related to abnormal iron metabolism. In the past decade, hepcidin, as a key factor in regulating iron metabolism, has attracted enormous attention due to its important role in the pathogenesis of ACD. This article reviews the research progress on the role and underlying regulatory mechanisms of hepcidin in ACD. We also discuss the potential of hepcidin as an effective therapeutic target for ACD treatment, in order to provide a new maneuver for improving the quality of ACD patients’ life.

Key words: anemia of chronic disease; iron metabolism; hepcidin; regulatory mechanism

Received: 　　Accepted:

Corresponding author: 史敏　　E-mail: sm8344@sina.com

DOI: 10.13294/j.aps.2022.0059

Citing This Article：

MI Hai-Chao, CUI Fang, DU Yu-Tao, WANG Ruo-Tong, ZHANG Rui, SHI Min. Research progress on the regulation mechanisms of iron metabolism in anemia of chronic disease. Acta Physiol Sin 2022; 74 (4): 639-647 (in Chinese with English abstract).