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Fibroblast growth factor 21 plays a protective role in cardiovascular diseases by inducing autophagy

LI Ying-Kai, HE Song-Yuan, WANG Cong, SHI Yu-Chen, LIU Jing-Hua^*

Center for Coronary Artery Disease, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung, and Blood Vessel Diseases, Beijing 100029, China

Abstract

Fibroblast growth factor 21 (FGF21) is a growth factor with endocrine function in the fibroblast growth factor family. Previous reports have shown that FGF21 is involved in the regulation of energy metabolism and plays a protective role in cardiovascular diseases such as coronary heart disease, diabetes, non-alcoholic fatty liver disease and so on. Recent studies have found that FGF21 can induce autophagy in a variety of tissues and organs, and autophagy is involved in many pathological processes of cardiovascular diseases, including vascular calcification, atherosclerosis, and myocardial ischemia-reperfusion injury. Therefore, FGF21 may play a protective role in a variety of cardiovascular diseases by regulating autophagy. This article reviews the research progress on the protective role of FGF21 in cardiovascular diseases by inducing autophagy.

Key words: fibroblast growth factor 21; autophagy; cardiovascular disease

Received: 　　Accepted:

Corresponding author: 柳景华　　E-mail: liujinghua@vip.sina.com

DOI: 10.13294/j.aps.2022.0061

Citing This Article：

LI Ying-Kai, HE Song-Yuan, WANG Cong, SHI Yu-Chen, LIU Jing-Hua. Fibroblast growth factor 21 plays a protective role in cardiovascular diseases by inducing autophagy. Acta Physiol Sin 2022; 74 (4): 633-638 (in Chinese with English abstract).