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Research progress of the regulation of cochlear sensitivity to noise by circadian rhythm

JIN Bao-Ling, WU Jing, CUI Zhong-Dan, TANG Jia, CHEN Qi-Cai, FU Zi-Ying^*

School of Life Sciences and Hubei Key Laboratory of Genetic Regulation and Integrative Biology, Central China Normal University, Wuhan 430079, China

Abstract

High level noise can damage cochlear hair cells, auditory nerve and synaptic connections between cochlear hair cells and auditory nerve, resulting in noise-induced hearing loss (NIHL). Recent studies have shown that animal cochleae have circadian rhythm, which makes them different in sensitivity to noise throughout the day. Cochlear circadian rhythm has a certain relationship with brain-derived neurotrophic factor and glucocorticoids, which affects the degree of hearing loss after exposure to noise. In this review, we summarize the research progress of the regulation of cochlear sensitivity to noise by circadian rhythm and prospect the future research direction.

Key words: noise-induced hearing loss; circadian rhythm; brain-derived neurotrophic factor; glucocorticoids; biological clock

Received: 　　Accepted:

Corresponding author: 付子英　　E-mail: ccnufuzy@mail.ccnu.edu.cn

DOI: 10.13294/j.aps.2022.0048

Citing This Article：

JIN Bao-Ling, WU Jing, CUI Zhong-Dan, TANG Jia, CHEN Qi-Cai, FU Zi-Ying. Research progress of the regulation of cochlear sensitivity to noise by circadian rhythm. Acta Physiol Sin 2022; 74 (3): 489-494 (in Chinese with English abstract).