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Neuro-immune interactions in respiratory diseases

YANG Zhong-Ying, ZANG Na, LIU En-Mei^*

Department of Respiratory Medicine, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Infection and Immunity, Chongqing 400014, China

Abstract

The nervous system and the immune system are relatively independent but interactional, and neuro-immune regulation is very important for the respiratory system to resist external harmful stimuli and to maintain homeostasis. Neuro-immune interaction is involved in the occurrence and development of respiratory diseases, and is essential for monitoring and modulating inflammation and tissue repair. This article summaries the neuro-immune regulation of respiratory system and discusses its role in respiratory diseases, aiming to provide a theoretical basis for further understanding the crosstalk between the nervous and immune systems, to explore the underlying mechanism in respiratory diseases, and to provide new thoughts for the prevention and treatment of respiratory diseases.

Key words: neuro-immune; neuro-immune crosstalk; respiratory diseases

Received: 　　Accepted:

Corresponding author: 刘恩梅　　E-mail: emliu186@126.com

DOI: 10.13294/j.aps.2022.0038

Citing This Article：

YANG Zhong-Ying, ZANG Na, LIU En-Mei. Neuro-immune interactions in respiratory diseases. Acta Physiol Sin 2022; 74 (3): 434-442 (in Chinese with English abstract).