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Neuroprotective effects of voluntary exercise and Yisaipu after traumatic brain injury in mice

GAN Tian-Tian¹, LIAO Qi¹, WANG Ji-Hui¹, FAN Zhi-Heng¹, CAO Jian¹, PAN Hui-Ju¹, LOU Gao-Feng², DONG Xue-Fen¹, OUYANG Wei^1,*

¹College of Physical Education and Health Sciences, Zhejiang Normal University, Jinhua 321004, China；²Department of Endocrinology, Zhejiang Jinhua Guangfu Hospital, Jinhua 321004, China

Abstract

The mechanisms underlying exercise-induced neuroprotective effects after traumatic brain injury (TBI) remained elusive, and there is a lack of effective treatments for TBI. In this study, we investigated the effects of an integrative approach of exercise and Yisaipu (TNFR-IgG fusion protein, TNF inhibitor) in a mouse TBI model. Male C57BL/6J mice were randomly assigned to a sedentary group or a group that followed a voluntary exercise regimen. The effects of 6-week prophylactic preconditioning exercise (PE) alone or in combination with post-TBI Yisaipu treatment on moderate TBI associated deficits were examined. The results showed that combined treatments of PE and post-TBI Yisaipu were superior to single treatments on reducing sensorimotor and gait dysfunctions in mice. These functional improvements were accompanied by reduced systemic inflammation largely via decreased serum TNF-α, boosted autophagic flux, and mitigated lesion volume after TBI. Given these neuroprotective effects, composite approaches such as a combination of exercise and TNF inhibitor may be a promising strategy for facilitating functional recovery from TBI and are worth further investigation.  

Key words: voluntary exercise; Yisaipu; traumatic brain injury; neurological deficits; motor disability

Received: 　　Accepted:

Corresponding author: 欧阳玮　　E-mail: wouyang@zjnu.cn

DOI: 10.13294/j.aps.2022.0037

Citing This Article：

GAN Tian-Tian, LIAO Qi, WANG Ji-Hui, FAN Zhi-Heng, CAO Jian, PAN Hui-Ju, LOU Gao-Feng, DONG Xue-Fen, OUYANG Wei. Neuroprotective effects of voluntary exercise and Yisaipu after traumatic brain injury in mice. Acta Physiol Sin 2022; 74 (3): 333-352