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The role of regulated cell death in renal ischemia-reperfusion injury

LIU Xin-Bei, LIU Wen-Jing^*

School of Medicine, Yunnan University, Kunming 650091, China

Abstract

Renal ischemia-reperfusion injury (IRI) is histologically characterized by tubular cell death. Diverse pathways of regulated cell death (RCD) have been reported to contribute to renal IRI in recent studies. In this review, we discuss the signaling pathways, regulators and crosstalk of RCD, including necroptosis, ferroptosis and pyroptosis, and their role in renal IRI in order to pave the way for new therapeutic opportunities.

Key words: renal ischemia-reperfusion injury; regulated cell death; necroptosis; ferroptosis; pyroptosis

Received: 　　Accepted:

Corresponding author: 刘文静　　E-mail: liuwenjing@ynu.edu.cn

DOI: 10.13294/j.aps.2022.0025

Citing This Article：

LIU Xin-Bei, LIU Wen-Jing. The role of regulated cell death in renal ischemia-reperfusion injury. Acta Physiol Sin 2022; 74 (2): 320-332 (in Chinese with English abstract).