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Emerging pathogenic role of group 3 innate lymphoid cells in inflammatory diseases

XIE Hui-Xin^1,2, GUO Yun^1,2, ZHONG Hao-Jie^1,2, ZHOU Yi^2,*, YU Xue-Qing^1,3

¹The First Clinical Medical College, Guangdong Medical University, Zhanjiang 524023, China；²Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University; Key Laboratory of Nephrology, National Health Commission and Guangdong Province, Guangzhou 510080, China；³Guangdong Provincial People’s Hospital; Guangdong Academy of Medical Sciences, Guangzhou 510080, China

Abstract

Group 3 innate lymphoid cells (ILC3) as a family member of innate lymphoid cells (ILCs), have been defined as novel innate immune cells in the past decade. ILC3 include a variety of heterogenous subsets with different phenotypes and functions, which are mainly distributed in barrier organs such as the intestine, lung and skin. They play an important role in immune regulation, tissue repair and lymphoid tissue formation. However, in various inflammatory diseases, ILC3 become dysregulated and participate in the pathogenesis through secreting a series of cytokines such as interleukin (IL)-17, IL-22, interferon-γ (IFN-γ) and granulocyte-macrophage colony-stimulating factor (GM-CSF) to modulate other immune cells and induce the formation of ectopic lymphoid structures. Therefore, it is of great significance to explore the phenotype and function of ILC3 in order to advance the understanding of inflammatory diseases and find new therapeutic targets. In this article, the phenotypic characteristics, biological functions and research progress of ILC3 in inflammatory diseases were reviewed.

Key words: group 3 innate lymphoid cells; inflammatory diseases; cytokines

Received: 　　Accepted:

Corresponding author: 周怡　　E-mail: zhouyi39@mail.sysu.edu.cn

DOI: 10.13294/j.aps.2022.0012

Citing This Article：

XIE Hui-Xin, GUO Yun, ZHONG Hao-Jie, ZHOU Yi, YU Xue-Qing. Emerging pathogenic role of group 3 innate lymphoid cells in inflammatory diseases. Acta Physiol Sin 2022; 74 (2): 265-275 (in Chinese with English abstract).