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Effect of high-intensity interval exercise on depression-related behavior in mice

LIU Jia-Hui^1,2, YANG Chao³, GU Qiu-Xiang¹, LIANG Hai-Ying⁴, LIU Dong^1,3, LIU Jun², LIU Tao², CAI Cheng-Yun^1,*

¹School of Life Science, Nantong University, Nantong 226001, China；²School of Sports Science, Nantong University, Nantong 226001, China；³Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong 226001, China；⁴Longyan First Hospital Affiliated to Fujian Medical University, Longyan 364000, China

Abstract

This paper was aimed to clarify the effect of high-intensity interval training (HIIT) on depression. Animal running platforms were used to establish HIIT exercise models, depression models were prepared by chronic unpredictable mild stress (CUMS), and depression-related behaviors were detected by behavioral experiments. The results showed that HIIT exercise improved depression-related behavior in CUMS model mice. Western blot and ELISA results showed that in the hippocampus, medial prefrontal cortex (mPFC) and amygdala of the CUMS model mice, glucocorticoid receptor (GR) protein expression was down-regulated, and the content of tumor necrosis factor α (TNF-α) was increased, compared with those in the control group, whereas HIIT exercise could effectively reverse these changes in CUMS model mice. These results suggest that HIIT exercise can exert antidepressant effect, which brings new ideas and means for the clinical treatment of depressive diseases.

Key words: high-intensity interval training; depression; glucocorticoid receptor; tumor necrosis factor α

Received: 　　Accepted:

Corresponding author: 蔡成云　　E-mail: caichengyun86@163.com

DOI: 10.13294/j.aps.2022.0024

Citing This Article：

LIU Jia-Hui, YANG Chao, GU Qiu-Xiang, LIANG Hai-Ying, LIU Dong, LIU Jun, LIU Tao, CAI Cheng-Yun. Effect of high-intensity interval exercise on depression-related behavior in mice. Acta Physiol Sin 2022; 74 (2): 165-176 (in Chinese with English abstract).