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Role and mechanism of non-coding RNA in the pathogenesis of acute kidney injury

WANG Peng, ZHOU Miao-Miao, NIE Jing^*

Division of Nephrology, Nanfang Hospital, Southern Medical University, State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Guangzhou 510515, China

Abstract

Acute kidney injury (AKI) is a common clinical syndrome and an independent risk factor of chronic kidney disease and end-stage renal failure. At present, the treatments of AKI are still very limited and the morbidity and mortality of AKI are rising. Non-coding RNAs (ncRNAs), including microRNAs, long non-coding RNAs and circular RNAs (circRNAs), are RNAs that are transcribed from the genome, but not translated into proteins. It has been widely reported that ncRNA is involved in AKI caused by ischemia reperfusion injury (IRI), drugs and sepsis through different molecular biological mechanisms, such as apoptosis and oxidative stress response. Therefore, ncRNAs are expected to become a new target for clinical prevention and treatment of AKI and a new biomarker for early warning of the occurrence and prognosis of AKI. Here, the role and mechanism of ncRNA in AKI and the research progress of ncRNA as biomarkers are reviewed.

Key words: acute kidney injury; non-coding RNA; microRNA; long non-coding RNA; circular RNA

Received: 　　Accepted:

Corresponding author: 聂静　　E-mail: niejing@smu.edu.cn

DOI: 10.13294/j.aps.2021.0097

Citing This Article：

WANG Peng, ZHOU Miao-Miao, NIE Jing. Role and mechanism of non-coding RNA in the pathogenesis of acute kidney injury. Acta Physiol Sin 2022; 74 (1): 39-46 (in Chinese with English abstract).