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Research progress of extracellular vesicles in the treatment of renal disease

TANG Tao-Tao, LYU Lin-Li, LIU Bi-Cheng^*

Institute of Nephrology, Zhongda Hospital, Southeast University, Nanjing 210009, China

Abstract

Extracellular vesicles (EVs) are lipid bilayer-enclosed structures containing diverse bioactive cargoes that play a major role in intercellular communication in both physiological and pathological conditions. Currently, the field of EV-based therapy has been rapidly growing, and two main therapeutic uses of EVs can be surmised: (i) exploiting stem cell-derived EVs as therapeutic agents; and (ii) employing EVs as natural therapeutic vectors for drug delivery. This review will discuss the recent advances in EV-based therapy in the treatment of renal disease.

Key words: extracellular vesicles; drug delivery; stem cell; acute kidney injury; chronic kidney disease

Received: 　　Accepted:

Corresponding author: 刘必成　　E-mail: liubc64@163.com

DOI: 10.13294/j.aps.2022.0004

Citing This Article：

TANG Tao-Tao, LYU Lin-Li, LIU Bi-Cheng. Research progress of extracellular vesicles in the treatment of renal disease. Acta Physiol Sin 2022; 74 (1): 67-72 (in Chinese with English abstract).