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Research progress of vascular endothelial growth factor-A and its isoforms in kidney disease

JING Jing, ZHONG Xin, LIU Bi-Cheng, LYU Lin-Li^*

JING Jing, ZHONG Xin, LIU Bi-Cheng, LYU Lin-Li* Institute of Nephrology, Zhongda Hospital, Southeast University, Nanjing 210009, China

Abstract

Vascular endothelial growth factor-A (VEGF-A) is a critical angiogenic factor which is mainly secreted from podocytes and epithelial cells in kidney and plays an important role in renal pathophysiology. In recent years, functions of different isoforms of VEGF-A and the new secretion approach via extracellular vesicles (EVs) have been identified. Thus, further understanding are needed for the role of VEGF-A and its isoforms in renal injury and repair. In this review, we summarized the expression, secretion and regulation of VEGF-A, its biological function, and the role of different isoforms of VEGF-A in the development of different renal diseases. Meanwhile, the research progress of VEGF-A as diagnostic marker and therapeutic target for renal diseases were discussed.

Key words: Vascular endothelial growth factor; renal disease; endothelial cell; extracellular vesicle; exosomes

Received: 　　Accepted:

Corresponding author: 吕林莉　　E-mail: lvlinli@seu.edu.cn

DOI: 10.13294/j.aps.2022.0008

Citing This Article：

JING Jing, ZHONG Xin, LIU Bi-Cheng, LYU Lin-Li. Research progress of vascular endothelial growth factor-A and its isoforms in kidney disease. Acta Physiol Sin 2022; 74 (1): 59-66 (in Chinese with English abstract).