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The renal metabolic mechanism of salt sensitive hypertension in Dahl-SS rats

CHEN Meng, YANG Peng-Fei, TIAN Zhong-Min^*

The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an 710049, China

Abstract

 The kidney is one of the main target organs involved in hypertension, and it regulates water and salt metabolism, blood volume and vascular resistance. High salt intake induces salt and water retention, persistent endothelial dysfunction and elevation of blood pressure in salt sensitive individuals. Dahl salt sensitive (Dahl-SS) rats, as a classic animal model for salt sensitive hypertension, have many similar stably inherited physiological characteristics to human with salt sensitive hypertension, such as salt sensitivity, hyperlipidemia, insulin resistance, renal failure, increased urinary protein secretion and low plasma renin activity. Based on renal physiology and biochemistry researches and multi-omics analyses in Dahl-SS rats, this review will summarize the relationship between salt sensitive hypertension and renal redox, NO, amino acids, glucose and lipid metabolism.

Key words: salt sensitive hypertension; Dahl-SS rats; oxygen free radicals; nitric oxide; amino acid metabolism; glucose metabolism; lipid metabolism

Received: 　　Accepted:

Corresponding author: 田中民　　E-mail: zmtian@mail.xjtu.edu.cn

DOI: 10.13294/j.aps.2022.0005

Citing This Article：

CHEN Meng, YANG Peng-Fei, TIAN Zhong-Min. The renal metabolic mechanism of salt sensitive hypertension in Dahl-SS rats. Acta Physiol Sin 2022; 74 (1): 47-58 (in Chinese with English abstract).