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Acute kidney injury and regulated cell death

NI Jia-Yun, LU Li-Min^*

Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China

Abstract

Acute kidney injury (AKI) refers to a clinical syndrome in which renal function declines rapidly in a short period of time caused by various pathological factors. During the development of AKI, renal tubules with the functions of reabsorption and excretion are prone to cell death due to external pathological stimuli, which is an important cause of impaired renal function. In recent years, a variety of new cell death pathways have been gradually recognized. Researchers have now found that regulated cell death (RCD), such as necroptosis, pyroptosis and ferroptosis, are important regulatory mechanisms of AKI. This article will summarize the research advances of various types of RCD involved in the process of AKI, aiming to deepen the understanding of AKI and provide innovative thoughts for the clinical treatment of AKI.

Key words: acute kidney injury; regulated cell death; necroptosis; pyroptosis; ferroptosis

Received: 　　Accepted:

Corresponding author: 陆利民　　E-mail: lulimin@shmu.edu.cn

DOI: 10.13294/j.aps.2022.0002

Citing This Article：

NI Jia-Yun, LU Li-Min. Acute kidney injury and regulated cell death. Acta Physiol Sin 2022; 74 (1): 4-14 (in Chinese with English abstract).