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Advances in the study of mitophagy-related receptor proteins

MA Rang-Gui¹, XIA Zhi^2,3, SHANG Hua-Yu^1,*

¹School of Sports Medicine and Health, Chengdu Sport University, Chengdu 610041, China；²College of Physical Education and Health, Wenzhou University, Wenzhou 325035, China；³Physical Education College of Jinggangshan University, Ji’an 343009, China

Abstract

Cells selectively scavenge redundant or damaged mitochondria by mitophagy, which is an important mechanism of mitochondrial quality control. Recent studies have shown that mitophagy is mainly regulated by autophagy-related genes (Atgs) in yeast cells, while mitochondrial membrane associated proteins such as PTEN-induced putative kinase 1 (PINK1), NIX/BNIP3L, BNIP3, FUN14 domain containing 1 (FUNDC1), FKBP8/FKBP38, Bcl-2-like protein 13 (Bcl2L13), nucleotide binding domain and leucine-rich-repeat-containing proteins X1 (NLRX1), prohibitin 2 (PHB2) and lipids such as cardiolipin (CL) are the key mitophagic receptors in mammalian cells, which can selectively recognize damaged mitochondria, recruit them into isolation membranes by binding to microtubule-associated protein 1 light chain 3 (LC3) or γ-aminobutyric acid receptor-associated protein (GABARAP), and then fuse with lysosomes to eliminate the trapped mitochondria. This article reviews recent research progress of mitophagy-related receptor proteins.

Key words: mitochondrion; autophagy; mitophagy; receptors

Received: 2021-01-27　　Accepted: 2021-05-06

Corresponding author: 尚画雨　　E-mail: santanasan@163.com

Citing This Article：

MA Rang-Gui, XIA Zhi, SHANG Hua-Yu. Advances in the study of mitophagy-related receptor proteins. Acta Physiol Sin 2021; 73 (6): 1025-1034 (in Chinese with English abstract).