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The role and mechanism of SIRT1 gene in depression

GUO Wei¹, XIAO Xi¹, TIAN Yu-Tao¹, YANG Jia-Jia^1,2,*

¹ Institute of Medical Engineering & Translational Medicine, Tianjin University, Tianjin 300072, China；²School of Precision Instrument and Opto-Electronics Engineering, Tianjin University, Tianjin 300072, China

Abstract

As a kind of mental illness, depression produces great difficulties in clinical diagnosis and treatment, and has a high disability rate. It is urgent to clarify the mechanism of depression to find potential therapeutic targets and effective clinical treatment methods. As a deacetylase, silent mating type information regulator 2 homolog 1 (SIRT1) is involved in many biological processes such as cell aging, cancer, and cardiovascular disease. In recent years, more and more studies have found that SIRT1 gene plays an important role in the pathogenesis of depression, but the mechanism is still unclear. Therefore, this review mainly summarizes the relevant research progress on the role and mechanism of SIRT1 gene in the hippocampus, prefrontal cortex, amygdala, hypothalamic suprachiasmatic nucleus, and nucleus accumbens in depression, in order to provide new ideas for exploring the mechanism and prevention of depression.

Key words: SIRT1; depression; hippocampus; prefrontal cortex; amygdala

Received: 2020-09-18　　Accepted: 2020-12-24

Corresponding author: 杨佳佳　　E-mail: jiajia.yang@tju.edu.cn

DOI: 10.13294/j.aps.2021.0028

Citing This Article：

GUO Wei, XIAO Xi, TIAN Yu-Tao, YANG Jia-Jia. The role and mechanism of SIRT1 gene in depression. Acta Physiol Sin 2021; 73 (5): 828-834 (in Chinese with English abstract).