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Developmental trend analysis and perspectives on researches related to hepatic glucose and lipid metabolism

SHI Lei^1,2, QU Hua³, ZHENG Hong-Ting³, WANG Xiu-Jie^1,2,*

¹Center for Molecular Systems Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China；²University of Chinese Academy of Sciences, Beijing 100049, China；³Department of Endocrinology, The Second Affiliated Hospital of Army Medical University, Chongqing 400037, China

Abstract

The balance of glucose and lipid metabolism is a coordinated result of multiple factors and organs, and is one of the fundamental requirements for the maintenance of human health. As the most important organ for human metabolism, liver plays a key role in regulating glucose and lipid metabolism. With the advances of researches, the number of publications related to hepatic glucose and lipid metabolism has increased rapidly, which posed a challenge for grasping the hot research topics and developmental trends of hepatic glucose and lipid metabolism in a short time. To solve such problem, we developed an information analysis method, which systematically analyzes the research status, research techniques, and hot research topics of the hepatic glucose and lipid metabolism research field through Medical Subject Headings (MeSH) of related papers and high-throughput experimental data. The results showed that the number of publications related to hepatic glucose and lipid metabolism, especially publications by Chinese scholars, has increased dramatically in this century, along with the remarkable increment of the numbers of authors and affiliations per paper. Such increment is in part positively correlated with the impact of publications. Nowadays, various types of high-throughput experimental techniques have become the main research methods for genetic studies of hepatic glucose and lipid metabolism. Transcription factors, such as peroxisome proliferator-activated receptors (PPARs), sterol regulatory element binding proteins (SREBPs), and NF-E2-related factor 2 (Nrf2), have become the new research hotspots. These results systematically showed the current focuses and developmental trends of hepatic glucose and lipid metabolism research, and the data analysis method developed in this work can also be applied to other research fields. 

Key words: Liver; glucose and lipid metabolism; publication analysis; MeSH term; GEO data

Received: 2021-01-04　　Accepted: 2021-07-12

Corresponding author: 王秀杰　　E-mail: xjwang@genetics.ac.cn

DOI: 10.13294/j.aps.2021.0068

Citing This Article：

SHI Lei, QU Hua, ZHENG Hong-Ting, WANG Xiu-Jie. Developmental trend analysis and perspectives on researches related to hepatic glucose and lipid metabolism. Acta Physiol Sin 2021; 73 (5): 781-794 (in Chinese with English abstract).