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Follicle-stimulating hormone: new roles in metabolic regulation and aging 

ZHAO Cai-Xia^*, LIU Peng

College of Basic Medicine, Shanxi Medical University, Taiyuan 030001, China

Abstract

Follicle-stimulating hormone (FSH) was once thought to play a role only in reproduction, promoting follicle development and maturation in women and spermgenesis in men. However, in recent ten years, FSH has been found to have new functions on metabolic regulation and aging. FSH regulates bone formation, fat metabolism, energy homeostasis, cholesterol production and cardiovascular disease by binding with its receptor FSHR. These newly discovered regulatory roles of FSH are exciting, as it is suggested that blocking FSH may have potential translational impacts on treatments of a series of age-related diseases, including osteoporosis, obesity, dyslipidemia, cardiovascular disease.

Key words: follicle-stimulating hormone; follicle-stimulating hormone receptor; osteoporosis; obesity; cholesterol; cardiovascular disease; aging

Received: 2020-11-18　　Accepted: 2021-09-23

Corresponding author: 赵彩霞　　E-mail: liupossible@gmail.com

DOI: 10.13294/j.aps.2021.0076

Citing This Article：

ZHAO Cai-Xia, LIU Peng. Follicle-stimulating hormone: new roles in metabolic regulation and aging . Acta Physiol Sin 2021; 73 (5): 755-760 (in Chinese with English abstract).