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The role of SIRT6 in nonalcoholic steatohepatitis

JING Xian-Dan^*, TANG Qin, HE Jin-Han

Laboratory of Clinical Pharmacy and Adverse Drug Reaction, West China Hospital, Sichuan University, Chengdu 610041, China

Abstract

SIRT6, a member of the silencing information regulatory protein family, is a nicotinamide adenine dinucleotide-dependent histone deacetylase and an ADP-ribose transferase enzyme. It plays an important role in fundamental physiological and pathological processes, including lipid metabolism, inflammation, oxidative stress and fibrosis, and is considered as a potential therapeutic target for metabolic syndrome. SIRT6 knockout mice displayed severe fatty liver, and the expression of SIRT6 in the liver of nonalcoholic steatohepatitis (NASH) mice was significantly lower than that of normal mice. Overexpression of SIRT6 significantly ameliorated NASH-induced liver damage. It is suggested that SIRT6 may play a key role in protecting against NASH. In this paper, we review the important regulatory functions of SIRT6 in the occurrence and development of NASH.

Key words: SIRT6; nonalcoholic steatohepatitis; lipid metabolism; inflammation; liver fibrosis

Received: 2021-01-20　　Accepted: 2021-07-16

Corresponding author: 敬贤丹　　E-mail: jinhanhe@scu.edu.cn

DOI: 10.13294/j.aps.2021.0074

Citing This Article：

JING Xian-Dan, TANG Qin, HE Jin-Han. The role of SIRT6 in nonalcoholic steatohepatitis. Acta Physiol Sin 2021; 73 (5): 745-754 (in Chinese with English abstract).