Issue Archive

The role of adenine nucleotide and its metabolites in regulating the homeostasis of glucose and lipid metabolism

GE Wen-Hao, LIU Jun-Hao, YANG Yun-Xia, ZHAO Yang, DING Zhao, ZHANG Jian-Fa^*

Center for Molecular Metabolism, Nanjing University of Science & Technology, Nanjing 210094, China

Abstract

Glucose and lipid metabolism is the most fundamental metabolic activity of higher organisms. This process is affected by both genetic polymorphisms and environmental factors. Excessive uptake and accumulation of lipids lead to obesity and disorder of glucose metabolic homeostasis characterized by insulin resistance and hyperglycemia, suggesting that the cross-regulation between lipid and glucose metabolism happens precisely at organ, cellular and molecular levels by known mechanisms. Adenine nucleotides and their metabolites have emerged as mediators in the mutual regulation of glucose and lipid metabolism. This review summarizes the roles of purinergic signaling induced by fatty acids in glucose metabolism and the development of type 2 diabetes.

Key words: glucose and lipid metabolism; adenine nucleotide; type 2 diabetes; insulin resistance; hyperglycemia

Received: 2020-11-22　　Accepted: 2021-03-12

Corresponding author: 张建法　　E-mail: jfzhang@mail.njust.edu.cn

DOI: 10.13294/j.aps.2021.0070

Citing This Article：

GE Wen-Hao, LIU Jun-Hao, YANG Yun-Xia, ZHAO Yang, DING Zhao, ZHANG Jian-Fa. The role of adenine nucleotide and its metabolites in regulating the homeostasis of glucose and lipid metabolism. Acta Physiol Sin 2021; 73 (5): 707-722 (in Chinese with English abstract).