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Role of prostaglandin E2 in the modulation of renal water transport 

LI Yu-Yuan¹, ZHANG Xiao-Yan^2,*

¹Advanced Institute for Medical Sciences, Dalian Medical University, Dalian 116044, China；²Health Science Center, East China Normal University, Shanghai 200241, China

Abstract

Prostaglandin E2 (PGE2), a bioactive lipid mediator, is one of the most important locally acting factors involved in a variety of physiological and pathophysiological processes. PGE2 binds with four EP receptors (EP1–4) to activate G protein-coupled receptor signaling responses. Recent functional and molecular studies have revealed that PGE2 plays an essential role in regulation of renal fluid transport via a variety of mechanisms. The water balance mainly depends on the regulation of aquaporin-2 (AQP2) by arginine vasopressin (AVP) in renal collecting duct principal cells. In recent years, increasing evidence suggests that PGE2 plays an important role in renal water reabsorption in the collecting ducts. In this paper, we reviewed the role of PGE2 and its receptors in the regulation of water reabsorption in the kidney, which may provide a new therapeutic strategy for many diseases especially nephrogenic diabetes insipidus. 

Key words: prostaglandin E2; water transport ; collecting ducts; arginine vasopressin; aquaporin-2

Received: 2020-11-17　　Accepted: 2021-02-08

Corresponding author: 张晓燕　　E-mail: xyzhang@hsc.ecnu.edu.cn

DOI: 10.13294/j.aps.2021.0055

Citing This Article：

LI Yu-Yuan, ZHANG Xiao-Yan. Role of prostaglandin E2 in the modulation of renal water transport . Acta Physiol Sin 2021; 73 (4): 681-689 (in Chinese with English abstract).