Issue Archive

Organoids derived from the digestive system and their perspective applications in exercise physiology

ZHANG Zi-Ye¹, XIANG Dao², LUO Bei-Bei^1,*

¹School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China；²Naval Research Institute, Naval Medical University, Shanghai 200433, China

Abstract

Organoid, formed from organ-specific cells, is a group of self-renewal and self-organizing cells growing in a 3-dimensional structure. With the recent progress on microenvironment regulation, stem cell differentiation and organ development, organoids have been constructed and used as promising tools for a wide range of multidisciplinary biomedical applications. Exercise disrupts the internal environment homeostasis, which brings a series of physiological alterations to the digestive system. The current animal or human models are necessary, but not sufficient to monitor the fluctuating microenvironment of gastrointestinal epithelial cells or hepatocytes during exercise. This review described the construction and application of digestive system organoids, as well as the effect of exercise on the microenvironment of intestinal epithelial cells and hepatocytes. The perspective applications of digestive system organoids in exercise physiology were also stated. Using organoid technologies, the possible mechanisms of the exercise- induced dynamic physiological changes would be explored in a new dimension.

Key words: gastrointestinal organoid; hepatic organoid; microenvironment; exercise; hypoxia

Received: 2020-08-11　　Accepted: 2021-01-25

Corresponding author: 罗贝贝　　E-mail: bluo@sus.edu.cn

DOI: 10.13294/j.aps.2021.0017

Citing This Article：

ZHANG Zi-Ye, XIANG Dao, LUO Bei-Bei. Organoids derived from the digestive system and their perspective applications in exercise physiology. Acta Physiol Sin 2021; 73 (3): 509-517 (in Chinese with English abstract).