Issue Archive

Current studies of cytokines in the pathogenesis of atherosclerosis and its therapeutic measures

LI Zhi-Ming, WANG Ming-Jie^*

Shanghai Key Laboratory of Bioactive Small Molecules, Department of physiology and pathophysiology, school of basic medical sciences, Shanghai Key Innovation Team of High-Level Local Universities, fudan university, shanghai 200032, China

Abstract

Atherosclerosis is a chronic inflammatory disease. Cytokine-related research provides an important direction for the prevention and treatment of atherosclerosis. Cytokines, produced by different types of cells and acting on a range of targets, play a key role in the pathogenesis and progression of atherosclerosis. This review summarizes the main pro-inflammatory and anti-inflammatory cytokines related to atherosclerosis and their underlying mechanism. We also outline current anti-atherosclerosis treatments targeting cytokines. The research and treatment prospects of cytokines in the prevention and treatment of atherosclerosis are discussed briefly as well.

Key words: Atherosclerosis; cytokines; inflammatory signal; therapy

Received: 2020-08-15　　Accepted: 2020-12-24

Corresponding author: 王铭洁　　E-mail: mjwang@shmu.edu.cn

DOI: 10.13294/j.aps.2021.0027

Citing This Article：

LI Zhi-Ming, WANG Ming-Jie. Current studies of cytokines in the pathogenesis of atherosclerosis and its therapeutic measures. Acta Physiol Sin 2021; 73 (3): 501-508 (in Chinese with English abstract).