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Dynamic characteristics of brain networks in patients with irritable bowel syndrome based on functional magnetic resonance imaging

NAN Jiao-Fen¹, MENG Pan-Ting¹, ZONG Nan-Nan¹, ZHANG Jin-Can^2,*

¹School of Computer and Communication Engineering, Zhengzhou University of Light Industry, Zhengzhou 450001, China；²School of Management Engineering, Zhengzhou University, Zhengzhou 450001, China

Abstract

The disorder of brain-gut interaction is an important cause of irritable bowel syndrome (IBS), but the dynamic characteristics of the brain remain unclear. Since there are many shortcomings for evaluating brain dynamic nature in the previous studies, we proposed a new method based on slope calculation by point-by-point analysis of the data from functional magnetic resonance imaging, and detected the abnormalities of brain dynamic changes in IBS patients. The results showed that compared with healthy subjects, there were dynamic changes in the brain for the IBS patients. After correction by false discovery rate (FDR), significant abnormalities were only found in two functional connections of the right posterior cingulate gyrus linked to left middle frontal gyrus, and the right posterior cingulate gyrus linked to left pallidus. The above results of the brain dynamic analysis were totally different from those of the brain static analysis of IBS patients. Our findings provide novel complementary information for illustrating the central nervous mechanism of IBS and may offer a new direction to explore central target for patients with IBS.

Key words: functional magnetic resonance imaging; brain; functional connectivity; dynamic characteristics; irritable bowel syndrome

Received: 2021-01-15　　Accepted: 2021-05-06

Corresponding author: 张金灿　　E-mail: zhangjincanzhengda@163.com

DOI: 10.13294/j.aps.2021.0033

Citing This Article：

NAN Jiao-Fen, MENG Pan-Ting, ZONG Nan-Nan, ZHANG Jin-Can. Dynamic characteristics of brain networks in patients with irritable bowel syndrome based on functional magnetic resonance imaging. Acta Physiol Sin 2021; 73 (3): 355-368 (in Chinese with English abstract).