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Research progress of the role of IGF-1 in metabolic diseases and the effect of exercise intervention

LI Bo-Wen, FENG Li-Li, TIAN Zhen-Jun^*

Department of Sports and Cardiovascular Health, Institute of Sports Biology, College of Physical Education, Shaanxi Normal University, Xi’an 710119, China

Abstract

Insulin-like growth factor-1 (IGF-1) is a peptide with a similar molecular structure to insulin. IGF-1 plays a key role in tissue growth and development, as well as cell metabolism, proliferation, differentiation and apoptosis. Liver is the main source of IGF-1, with the production of IGF-1 up to 75% of the total in the whole body, while the remaining 25% are secreted by skeletal muscles, heart, kidney, spleen and other organs. Target organs of IGF-1 include heart, blood vessels, liver, bone and skeletal muscles. It has been well documented that IGF-1 plays an important role in the prevention and treatment of metabolic diseases. Different types of exercise have different effects on IGF-1 expression with organ differences. In this article, we reviewed the preventive and therapeutic effects of IGF-1 on metabolic diseases and IGF-1-mediated exercise-induced benefits.

Key words: insulin-like growth factor-1; metabolic diseases; exercise

Received: 2020-06-18　　Accepted: 2020-11-04

Corresponding author: 田振军　　E-mail: tianzhj@snnu.edu.cn

DOI: 10.13294/j.aps.2021.0014

Citing This Article：

LI Bo-Wen, FENG Li-Li, TIAN Zhen-Jun. Research progress of the role of IGF-1 in metabolic diseases and the effect of exercise intervention. Acta Physiol Sin 2021; 73 (2): 342-352 (in Chinese with English abstract).