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Research progress on pyroptosis and cardiovascular diseases

WANG Jia-Hui^1,2, LIANG Huan^1,2, YU Ying^1,2, GAO Qin^1,2,*

¹Department of Physiology, Bengbu Medical College, Bengbu 233000, China；²Key Laboratory of Basic and Clinical Cardiovascular Diseases, Bengbu Medical College, Bengbu 233000, China

Abstract

Pyroptosis is a form of programmed cell death which is closely related to the inflammatory response, mediated by Gasdermin protein and depends on the activity of cysteine aspartate specific protease (caspase). Pyroptosis is typically characterized by swelling and rupture of cell membrane, release of proinflammatory factors and cell contents from the plasma membrane to the extracellular environment, which aggravates inflammatory response. During the inflammatory response, NLRP3, caspase, Gasdermin D (GSDMD) and IL-1β play important roles in the occurrence and development of cardiovascular diseases. In this review, we focus on the role of pyroptosis in cardiovascular diseases including atherosclerosis, coronary heart disease, myocardial infarction, diabetic cardiomyopathy, pressure overload-induced ventricular remodeling and cardiac hypertrophy, myocarditis, arrhythmia and so on, and summarize the potential treatment targeting pyroptosis. It will provide the basis for prevention and treatment of clinical cardiovascular diseases.

Key words: pyroptosis; Gasdermin; caspase; inflammasome; cardiovascular disease

Received: 2020-04-20　　Accepted: 2020-08-17

Corresponding author: 高琴　　E-mail: bbmcgq@126.com

DOI: 10.13294/j.aps.2020.0063

Citing This Article：

WANG Jia-Hui, LIANG Huan, YU Ying, GAO Qin. Research progress on pyroptosis and cardiovascular diseases. Acta Physiol Sin 2021; 73 (2): 329-341 (in Chinese with English abstract).