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New insights into vascular mechanobiology: roles of matrix mechanics in regulating smooth muscle cell function

WANG Jin^1,2,3, ZHU Juan-Juan^1,2,3, ZHOU Jing^1,2,3,*

¹Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing 100191, China；²Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing 100191, China；³Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, National Health Commission, Beijing 100191, China

Abstract

Vascular smooth muscle cell (vSMC) is the predominant cell type in the blood vessel wall and is constantly subjected to a complex extracellular microenvironment. Mechanical forces that are conveyed by changes in stiffness/elasticity, geometry and topology of the extracellular matrix have been indicated by experimental studies to affect the phenotype and function of vSMCs. vSMCs perceive the mechanical stimuli from matrix via specialized mechanosensors, translate these stimuli into biochemical signals controlling gene expression and activation, with the consequent modulation in controlling various aspects of SMC behaviors. Changes in vSMC behaviors may further cause disruption of vascular homeostasis and then lead to vascular remodeling. A better understanding of how SMC senses and transduces mechanical forces and how the extracellular mechano-microenvironments regulate SMC phenotype and function may contribute to the development of new therapeutics for vascular diseases.

Key words: Vascular smooth muscle cells;;;;

Received: 2020-05-14　　Accepted: 2021-03-11

Corresponding author: 周菁　　E-mail: jzhou@bjmu.edu.cn

DOI: 10.13294/j.aps.2021.0018

Citing This Article：

WANG Jin, ZHU Juan-Juan, ZHOU Jing. New insights into vascular mechanobiology: roles of matrix mechanics in regulating smooth muscle cell function. Acta Physiol Sin 2021; 73 (2): 160-174 (in Chinese with English abstract).