Issue Archive

New advances in oxygen sensing and adaptive mechanism

SHEN An-Ran¹, WANG Bin^1,2, LIU Bi-Cheng^1,2,*

¹Institute of Nephrology, Southeast University, Nanjing 210009, China；²Department of Nephrology, Zhongda Hospital, Southeast University, Nanjing 210009, China

Abstract

Under the hypoxic condition, organs or cells trigger a series of reactions or responses to adapt to the physiological requirement. These responses involve a complex regulation at different levels from organs, in particular the kidney (producing erythropoietin), to cells throughout the body. Actually, the responses to hypoxia from adaption to injury largely depend on the degree and time of hypoxia.  In the past two decades, with the discovery of hypoxia-inducible factor (HIF), the mechanisms of erythropoiesis regulation were elucidated gradually, which has provided a novel therapeutic strategy for hypoxia-related diseases, especially renal anemia. In this review we focus on the latest advances in oxygen sensing and adaptive mechanism.

Key words: oxygen sensing; adaption; mechanism

Received: 2019-12-09　　Accepted: 2020-01-29

Corresponding author: 刘必成　　E-mail: liubc64@163.com

DOI: 3294/j.aps.2020.0068

Citing This Article：

SHEN An-Ran, WANG Bin, LIU Bi-Cheng. New advances in oxygen sensing and adaptive mechanism. Acta Physiol Sin 2020; 72 (5): 660-666 (in Chinese with English abstract).