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The metabolic networks of ferroptosis and links to lung diseases

CHENG Hai-Peng¹, FENG Dan-Dan¹, YUE Shao-Jie², LUO Zi-Qiang^1,*

¹Department of Physiology, Xiangya School of Medicine, Central South University, Changsha 410078, China；²Department of Pediatrics, Xiangya Hospital, Central South University, Changsha 410078, China

Abstract

Ferroptosis is a newly discovered non-apoptotic form of regulated cell death driven by iron-dependent lipid peroxidation. The present studies have shown that many metabolic processes and homeostasis are affected by ferroptosis. It is related to many lung diseases, including acute lung injury, chronic obstructive pulmonary disease and pulmonary fibrosis, etc. Currently, the research on ferroptosis is still in its infancy. Previous studies have confirmed that ferroptosis is regulated by a variety of genes, and the mechanism is complex, mainly involving iron homeostasis and lipid peroxidation metabolism. This review summarizes some regulation networks of metabolic processes associated with ferroptosis and discusses the roles of ferroptosis in the pathophysiological progression of many lung diseases. We expected to provide new ideas and references for the treatment of these diseases.

Key words: ferroptosis; metabolic networks; acute lung injury; chronic obstructive pulmonary disease; pulmonary fibrosis

Received: 2020-05-21　　Accepted: 2020-08-17

Corresponding author: 罗自强　　E-mail: luoziqiang@csu.edu.cn

DOI: 10.13294/j.aps.2020.0069

Citing This Article：

CHENG Hai-Peng, FENG Dan-Dan, YUE Shao-Jie, LUO Zi-Qiang. The metabolic networks of ferroptosis and links to lung diseases. Acta Physiol Sin 2020; 72 (5): 566-574 (in Chinese with English abstract).