ISSN 0371-0874, CN 31-1352/Q

Issue Archive

Advances in molecular mechanisms of meiotic arrest and luteinizing hormone-induced meiotic resumption in oocytes

HAO Xiao-Qiong1,2,*, XU Shao-Kai3, SHI Rui-Li1

1Department of Physiology, Baotou Medical College, Baotou 014040, China;2State Key Laboratory for Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing 100094, China;3First Affiliated Hospital, Baotou Medical College, Baotou 014040, China

Abstract

Mammalian oocytes within Graafian follicles are arrested at prophase I of meiosis. C-type natriuretic peptide (NPPC), secreted by mural granulosa cells (MGCs), maintains oocyte meiotic arrest via binding to its cognate receptor natriuretic peptide receptor 2 (NPR2) and producing cyclic guanosine monophosphate (cGMP). NPR2 is most concentrated in the cumulus cells. In addition, cAMP, gap junction, inosine monophosphate dehydrogenase (IMPDH) and other important regulatory factors are also involved in meiotic arrest. Luteinizing hormone (LH) then rapidly decreases cGMP and induces oocyte meiotic resumption. In this paper, advances in the molecular mechanisms of meiotic arrest and LH-induced meiotic resumption were reviewed. This paper may provide new ideas for the prevention, diagnosis and treatment of related reproductive diseases.

Key words: meiosis; cyclic guanosine monophosphate; C-type natriuretic peptide; natriuretic peptide receptor 2; luteinizing hormone

Received: 2019-09-23  Accepted: 2020-03-20

Corresponding author: 郝肖琼  E-mail: haoxiaoqiong@126.com

DOI: 10.13294/j.aps.2020.0052

Citing This Article:

HAO Xiao-Qiong, XU Shao-Kai, SHI Rui-Li. Advances in molecular mechanisms of meiotic arrest and luteinizing hormone-induced meiotic resumption in oocytes. Acta Physiol Sin 2020; 72 (4): 513-522 (in Chinese with English abstract).