Advances in molecular mechanisms of meiotic arrest and luteinizing hormone-induced meiotic resumption in oocytes
HAO Xiao-Qiong1,2,*, XU Shao-Kai3, SHI Rui-Li1
1Department of Physiology, Baotou Medical College, Baotou 014040, China;2State Key Laboratory for Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing 100094, China;3First Affiliated Hospital, Baotou Medical College, Baotou 014040, China
Abstract
Mammalian oocytes within Graafian follicles are arrested at prophase I of meiosis. C-type natriuretic peptide (NPPC), secreted by mural granulosa cells (MGCs), maintains oocyte meiotic arrest via binding to its cognate receptor natriuretic peptide receptor 2 (NPR2) and producing cyclic guanosine monophosphate (cGMP). NPR2 is most concentrated in the cumulus cells. In addition, cAMP, gap junction, inosine monophosphate dehydrogenase (IMPDH) and other important regulatory factors are also involved in meiotic arrest. Luteinizing hormone (LH) then rapidly decreases cGMP and induces oocyte meiotic resumption. In this paper, advances in the molecular mechanisms of meiotic arrest and LH-induced meiotic resumption were reviewed. This paper may provide new ideas for the prevention, diagnosis and treatment of related reproductive diseases.
Key words: meiosis; cyclic guanosine monophosphate; C-type natriuretic peptide; natriuretic peptide receptor 2; luteinizing hormone
Received: 2019-09-23 Accepted: 2020-03-20
Corresponding author: 郝肖琼 E-mail: haoxiaoqiong@126.com
DOI: 10.13294/j.aps.2020.0052
Citing This Article:
HAO Xiao-Qiong, XU Shao-Kai, SHI Rui-Li. Advances in molecular mechanisms of meiotic arrest and luteinizing hormone-induced meiotic resumption in oocytes. Acta Physiol Sin 2020; 72 (4): 513-522 (in Chinese with English abstract).