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Progress in regulation of mitochondrial dynamics and mitochondrial autophagy

CHENG Jing, WEI Lin, LI Miao^*

Department of Immunology, Hebei Medical University; Key Laboratory of Immune Mechanism and Intervention of Major Diseases in Hebei Province, Shijiazhuang 050000, China

Abstract

The abnormality of mitochondrial morphology and function is closely related to the pathogenesis of many diseases. Mitochondrialfusion-fission dynamics are critical to maintain normal morphology, distribution and quantity of mitochondria, and ensurethe normal activity of cells. In addition, mitochondrial autophagy (mitophagy) plays an important role in maintaining mitochondrialquality by degrading aging or damaged mitochondria. Many previous studies showed that mitochondrial dynamics and mitophagy canregulate each other to sustain mitochondrial network homeostasis. Clarifying regulatory mechanisms of mitochondrial dynamics andmitophagy is of great significance for revealing the molecular mechanism of various diseases and for the development of new drugstargeting mitochondrial dynamics proteins or mitophagy regulatory proteins. This review focuses on the role of mitochondrial dynamicsand mitophagy in mitochondrial quality control, regulatory mechanism, the interplay between those two processes, and their roles inhuman-related diseases.

Key words: mitochondrial homeostasis; mitophagy; mitochondrial dynamics; regulation mechanisms

Received: 2019-06-17　　Accepted: 2019-12-16

Corresponding author: 李苗　　E-mail: lmiao0214@163.com

DOI: 10.13294/j.aps.2020.0025

Citing This Article：

CHENG Jing, WEI Lin, LI Miao. Progress in regulation of mitochondrial dynamics and mitochondrial autophagy. Acta Physiol Sin 2020; 72 (4): 475-487 (in Chinese with English abstract).