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Role of calcitonin gene-related peptide in regulation of synaptic plasticity and process of the emotional memory

WU Xin, WANG Dong-Hui, GAO Jian-Feng^*

School of Basic Medicine, Henan University of Chinese Medicine, Zhengzhou 450046, China

Abstract

Calcitonin gene-related peptide (CGRP) is a neuropeptide coded by the calcitonin gene and divided into α and β subtypes. CGRP is widely distributed throughout the human body and highly expressed in the peripheral and central nervous system. Studies have shown that CGRP plays a role in a variety of physiological and pathophysiological activities, such as the formation and transmission of nociceptive signal, as well as the regulation of cardiovascular function. Recently, more and more researches have shown that CGRP is involved in the regulation of synaptic plasticity, cognitive function and learning memory in the central nervous system. This paper reviews the role of CGRP in regulation of synaptic plasticity and process of emotional memory, hoping to provide a new molecular target and theoretical basis for clinical treatment of neurological diseases.

Key words: Calcitonin gene-related peptide; cognition; emotional memory; synaptic plasticity; glutamate receptor

Received: 2019-03-21　　Accepted: 2019-07-03

Corresponding author: 高剑峰　　E-mail: jc.gjfeng@hotmail.com

DOI: 10.13294/j.aps.2019.0067

Citing This Article：

WU Xin, WANG Dong-Hui, GAO Jian-Feng. Role of calcitonin gene-related peptide in regulation of synaptic plasticity and process of the emotional memory. Acta Physiol Sin 2020; 72 (3): 399-406 (in Chinese with English abstract).