Issue Archive

The effects and mechanism of caloric restriction on energy metabolism

FAN Xiao-Na, CHEN Lin-Xi, XU Ge-Yang^*

Department of Physiology, School of Medicine, Jinan University, Guangzhou 510632, China

Abstract

Caloric restriction (CR) is explored to limit the caloric intake without malnutrition. CR can affect the levels of various metabolites in organism, such as lipids, free fatty acids, ketones, bile acids and amino acids, etc, and is thought being able to extend the lifespan, postpone and reduce the incidence of age-related disorders (e.g., type 2 diabetes, cancer and cardiovascular diseases). These effects are mainly attributed to the role of CR in energy metabolism. The mechanism of CR on energy metabolism is closely related to biological clock, hormonal production, gastrointestinal flora and inflammation. Here we briefly review the effects and mechanism of CR on energy metabolism.

Key words: caloric restriction; energy metabolism; hormone; biological clock; gastrointestinal flora; inflammation

Received: 2019-09-17　　Accepted: 2020-02-04

Corresponding author: 许戈阳　　E-mail: xugeyangliang@163.com

DOI: 10.13294/j.aps.2020.0030

Citing This Article：

FAN Xiao-Na, CHEN Lin-Xi, XU Ge-Yang. The effects and mechanism of caloric restriction on energy metabolism. Acta Physiol Sin 2020; 72 (3): 371-381 (in Chinese with English abstract).