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Effects and pathophysiological significance of intestinal flora on the enteric neuro-endocrine-immune system

XU Han-Nan, CAI Zheng-Zhen, WANG Yun, WU Duo-Er, RONG Wei-Fang, ZHANG Guo-Hua^*

Department of Anatomy and Physiology, Basic Medical School, Shanghai Jiao Tong University, Shanghai 200025, China

Abstract

Interactions among the nervous, the endocrine and the immune systems enable the gut to respond to the dietary products, pathogens and microbiota, which maintains the homeostasis of the body. However, dysbiosis may induce or aggravate the gastrointestinal (GI) and extra-GI diseases through changing the activities of enteric nervous system (ENS), enteroendocrine cells and enteric immune cells. Here we review recent advances in the understandings on how intestinal flora may impact the enteric neuro-endocrine-immune system in the gut, thereby contributing to the regulation of pathophysiological processes.

Key words: intestinal flora; enteric nervous system; enteroendocrine cells; enteric immune cells

Received: 2019-10-25　　Accepted: 2020-03-20

Corresponding author: 张国花　　E-mail: ghzhang2009@shsmu.edu.cn

DOI: 10.13294/j.aps.2020.0033

Citing This Article：

XU Han-Nan, CAI Zheng-Zhen, WANG Yun, WU Duo-Er, RONG Wei-Fang, ZHANG Guo-Hua. Effects and pathophysiological significance of intestinal flora on the enteric neuro-endocrine-immune system. Acta Physiol Sin 2020; 72 (3): 347-360 (in Chinese with English abstract).