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Research progress of kisspeptin in female reproductive endocrine and assisted reproductive techniques

ZHANG Yi, SUN Ning-Xia^*

Reproductive Medicine Center, the Second Affiliated Hospital of Naval Military Medical University, Shanghai 200003, China

Abstract

In recent years, it has been found that kisspeptin plays some key roles in the physiological processes of the brain, such as gender differentiation, positive and negative feedback of sex hormones, onset of puberty, and transduction of energy signals in the body, which suggests that kisspeptin may be a key molecule for the maturation and regulation of female reproductive function. In addition to the systemic roles of the kisspeptin, its local roles in reproductive organs are constantly being discovered. With the discovery that kisspeptin is involved in the pathological process of reproductive endocrine diseases such as isolated hypogonadotropic hypogonadism (IHH), polycystic ovary syndrome (PCOS), premature ovarian failure (POF) and pathological hyperprolactinemia, exogenous application of kisspeptin to solve reproductive problems has become a new hot topic. The review focuses on the research progress of kisspeptin in the female reproductive system, especially on its application in assisted reproduction.

Key words: kisspeptin; reproductive physiological phenomena; infertility, female; reproductive techniques, assisted

Received: 2019-08-05　　Accepted: 2020-01-02

Corresponding author: 孙宁霞　　E-mail: suesunchzh@126.com

DOI: 10.13294/j.aps.2020.0008

Citing This Article：

ZHANG Yi, SUN Ning-Xia. Research progress of kisspeptin in female reproductive endocrine and assisted reproductive techniques. Acta Physiol Sin 2020; 72 (1): 125-132 (in Chinese with English abstract).