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Advances in proteomic studies of post-translational modifications during spermatogenesis

ZHU Tian-Yu¹, LI Yan^1,2, LIU Xiao-Fei¹, QI Ya-Ling¹, GUO Xue-Jiang^1,*

¹State Key LaboratoryNanjing Medical University, Nanjing 211166, China of Reproductive Medicine, ；²Center of Pathology and Clinical Laboratory, Sir Run Run Hospital, Nanjing Medical University, Nanjing 211166, China

Abstract

Spermatogenesis is composed of a series of complex biological events, which are regulated by complex factors. There is a phenomenon of delayed translation in spermatogenesis, so the changes of transcription and protein expression are not completely consistent. Thus post-translational modifications (PTMs) play a key role in spermatogenic biological events. In recent years, the development of proteomics has deepened the discovery of PTM. This paper reviews the advances in multiple PTMs proteomic during testicular spermatogenesis. Their effects on sperm function and fertility, as well as their significance for future diagnosis and treatment are discussed.

Key words: Spermatogenesis; post-translational modifications; proteomics

Received: 2019-07-15　　Accepted: 2019-11-25

Corresponding author: 郭雪江　　E-mail: guo_xuejiang@njmu.edu.cn

DOI: 10.13294/j.aps.2020.0007

Citing This Article：

ZHU Tian-Yu, LI Yan, LIU Xiao-Fei, QI Ya-Ling, GUO Xue-Jiang. Advances in proteomic studies of post-translational modifications during spermatogenesis. Acta Physiol Sin 2020; 72 (1): 75-83 (in Chinese with English abstract).